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Arginase Assay Utilizing a Fluorometric-Based Coupled Enzyme System
Reference #: 1752
The University of South Carolina is offering licensing opportunities for Arginase Assay Utilizing a Fluorometric-Based Coupled Enzyme System.
Background:
The enzyme arginase is typically assayed for activity by either colorimetry, fluorimetry, or detecting for the concentration of radiolabeled isotopes. In most of the methodologies...
Published: 6/26/2026
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Updated: 2/17/2026
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Inventor(s): Edward D'antonio
Keywords(s):
Category(s): Chemistry and Biochemistry
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Therapeutic gossypol-based inhibitors of glucose kinases for parasitic diseases
Reference #: 01658
The University of South Carolina is offering licensing opportunities for therapeutic gossypol-based inhibitors of glucose kinases for parasitic diseases.
Background:
Trypanosoma cruzi and Trypanosoma brucei, which are protozoan parasites pathogenic to the human host are the etiological agents of Chagas' disease and human African...
Published: 10/6/2025
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Updated: 4/26/2024
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Inventor(s): Edward D'antonio
Keywords(s):
Category(s): Biomedical and Life Sciences
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One-Step Synthesis of Phosphate-Based Inhibitors and Applications Thereof
Reference #: 01236
The University of South Carolina is offering licensing opportunities for using ribose 5-phosphate isomerase inhibitors to treat against kinetoplastid parasites.
Background
Trypanosoma cruzi protozoa are the causative agent for Chagas’ disease, a neglected tropical disease that affects 6 – 7 million people worldwide....
Published: 6/7/2021
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Updated: 5/13/2021
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Inventor(s): Edward D'antonio, Joshua Pierce
Keywords(s):
Category(s): Health Sciences, Biomedical and Life Sciences
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Inhibitors of Glucose Kinases: Update 2-27-2019
Reference #: 01401
The University of South Carolina is offering licensing opportunities for Monosaccharide Amine and 3-Nitro-2-Phenyl-2H-Chromene Based Inhibitors of Glucose Kinases
Background:
When a kissing bug bites a human, they can be infected with a Kinetoplastid parasite such as Trypanosoma cruzi (T. cruzi). A need exists for new drugs that...
Published: 9/4/2022
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Updated: 10/24/2019
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Inventor(s): Edward D'antonio
Keywords(s): African Sleeping Sickness, Chagas' Disease, drug discovery, Glucokinase, Glucose Kinases, Glycolysis, Hexokinase, High-Throughput Screen, HTS, inhibitor, Inhibitor constant (Ki), Leishmanisis, Parasite, Parasitic Infections, Pentose Phosphate Pathway, Trypanosoma brucei, Trypanosoma cruzi, Trypanosome
Category(s): Chemistry and Biochemistry, Biomedical and Life Sciences
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Cysteine-Modifying Substrate Analogue Inhibitors of Ribose 5-Phosphate Isomerase
Reference #: 01181 The University of South Carolina is offering licensing opportunities for strong selective inhibitors of the ribose 5-phosphate isomerase enzyme as new drug alternatives to commonly prescribed therapies for Chagas’ disease, African sleeping sickness, and leishmaniasis.Invention Description: Kinetoplastid parasites such as Trypanosoma...
Published: 5/27/2021
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Updated: 6/26/2016
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Inventor(s): Edward D'antonio
Keywords(s):
Category(s): Biomedical and Life Sciences, Chemistry and Biochemistry, Health Sciences
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Therapeutic Inhibitors of Hexokinase and Glucokinase
Reference #: 01133
The University of South Carolina is offering licensing opportunities for new enzyme inhibitors for therapeutic drugs that treat diseases caused by trypanosomal parasites including Chagas’ disease and African sleeping sickness.
Invention Description:
Trypanosomal parasites, such as Trypansoma cruzi and Trypansoma brucei, utilize...
Published: 9/11/2025
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Updated: 1/16/2015
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Inventor(s): Edward D'antonio, Jennifer D'antonio
Keywords(s):
Category(s): Biomedical and Life Sciences, Health Sciences, Chemistry and Biochemistry
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